廉哲雄,教 授,博士生导师。教育部长江计划特聘教授,中科院“百人计划”获得者,安徽省“百人计划”特聘专家。
1989年毕业于白求恩医科大学(现吉林大学白求恩医学部)获得医学学士学位,1998年日本关西医科大学获医学博士学位。曾为美国纽约大学北岸医院助理研究员(1998-2000),美国加利福尼亚大学戴维斯分校博士后(2000-2003),美国加利福尼亚大学戴维斯分校资深研究员(2003-2007),美国加利福尼亚大学戴维斯分校副教授(2007-2009)。2009年作为中国科学院“百人计划”引进人才受聘于中国科技大学生命科学学院/免疫所,入选2009年度“教育部长江计划特聘教授”。在肝脏自身免疫性疾病免疫学研究方面有较高国际声望。在J.Exp.Med., J.C.I., Gastroenterology, Hepatology, J.Immunol.等杂志发表SCI论文九十余篇。
主要研究兴趣(方向):自身免疫性疾病和肝脏基础免疫学研究
1)自身免疫性肝病的细胞和分子生物学发病机制
2)自身免疫性肠炎的细胞和分子生物学发病机制
3)开发新一代治疗自身免疫性疾病的靶点免疫药物
主要代表论文:
1. Wang Y-H, Yang W, Yang J-B, Jia Y-J, Tang W, Gershwin ME, William M. Ridgway and Lian Z-X*. (2015) Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis. J Autoimmunity. In press. (Corresponding author).
2. Ma H-D, Wang Y-H, Chang C, Gershwin ME and Lian Z-X*. (2015) The Intestinal Microbiota and Microenvironment in Liver. Autoimmunity Reviews. 14:183-191. (Corresponding author).
3. Yang W, Yao Y, Yang Y-Q, Lu F-T, Li L, Wang Y-H, Nakajima T, Tsuneyama K, Ridgway WM, Gershwin ME and Lian Z-X*. (2014) Differential Modulation by IL-17A of Cholangitis Versus Colitis in IL-2R Deleted Mice. Plos One (2013 IF:3.73). 9:e105351. (Corresponding author).
4. Yao Y, Yang W, Yang Y-Q, Ma H-D, Lu F-T, Li L, Tao Y-Y, Tsuneyama K, Zhang W, Friedman S, Gershwin ME and Lian Z-X*. (2014) Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Rα-/- mice. J Autoimmunity. 51:99-108. (Corresponding author).
5. Deng Y-R, Yoshida K, Jin Q, Murata M, Yamaguchi T, Tsuneyama K, Moritoki Y, Niu J, Matsuzaki K and Lian Z-X*. (2014) Reversible phosphor-Smad3 signaling between tumor-suppression and fibro-carcinogenesis in chronic hepatitis B infection. Clinical Experimental Immunology. 176:102-111. (Corresponding author).
6. Deng Y-R, Ma H-D, Tsuneyama K, Yang W, Wang Y-H, Lu F-T, Liu C-H, Liu P, He X-S, Diehl AM, Gershwin ME and Lian Z-X*. (2013) STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. J Autoimmunity. 49:25-34. (Corresponding author).
7. Ma HD, Deng YR, Tian Z and Lian Z-X*.(2013) Traditional Chinese Medicine and Immune Regulation.Clin Rev Allergy Immunol. 44:229-241. (Corresponding author).
8. Tsuda M, Zhang W, Yang GX, Tsuneyama K, Ando Y, Kawata K, Park O, Leung P, Coppel RL, Ansari AA, Ridgway WM, Gao B, Lian Z-X*, Flavell R, He XS and Gershwin ME*. (2013) Deletion of IL-12p35 induces liver fibrosis in dominant negative transforming growth factor β receptor type II mice. Hepatology. 57:806-16. (*Equally Corresponding author).
9. Shu SA, Ma HD and Lian Z-X*. (2012) Ontogenic Development and Population Dynamics of Hepatic Dendritic Cells. Current Immunology Reviews. 8:3-11. (Corresponding author).
联系方式:
电话:0551-6360-0317
电子邮件:zxlian1@ustc.edu.cn