教授,博士生导师
中国科学院“百人计划”(2011)获得者。2001年毕业于华中科技大学生物系,获理学学士学位;2006年毕业于华中科技大学生物物理专业,获理学博士学位;2006至2010年在霍华德休斯医学研究所,芝加哥大学从事博士后研究。主要研究成果分别发表在Cell Metab,PNAS等期刊上, 获Faculty of 1000好评和推荐。现承担国家重大研究计划及国家自然科学基金委等研究课题。
研究兴趣:
1)NKT细胞的功能;
2)NKT细胞与代谢炎症
主要代表性论文:
1. Bai L*, Deng SL* , Reboulet R*, Mathew R , Teyton L, Savage PB , Bendelac A. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proc Natl AcadSci U S A. 2013 Oct 1;110(40):16097-102.(co-corresponding)
2. Bai L*, Picard D*, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A.The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR.Eur J Immunol.2012 Sep; 42(9):2505-10.
3. Bai L, Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB, Bendelac A.Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo.J Immunol.2012 Apr 1;188(7):3053-61.(co-corresponding).
4. Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB, Bendelac A.Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen GC. Proc Natl AcadSci U S A. 2009 Jun 23;106(25):10254-9.
5. Jiang L*, Fan J*, Bai L*, Wang Y, Chen Y, Yang L, Chen L, Xu T. Direct Quantification of Fusion Rate Reveals a Distal Role for AS160 in Insulin-stimulated Fusion of GLUT4 Storage Vesicles. J Biol Chem. 2008 Mar 28; 283(13): 8508-16.
6. Yuval Sagiv, Li Bai, Datsen G. Wei, Reuven Agami, Paul B. Savage, Luc Teyton, and Albert Bendelac. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med. 2007 Apr 2.
7. Bai L*, Wang Y*, Fan J*, Chen Y, Ji W, Qu A, Xu P, James DE, Xu T. Dissecting multiple steps of GLUT4 trafficking and identifying the sites of insulin action.Cell Metab.2007 Jan; 5(1): 47-57.
8. Bai L*,Dan Zhu*, Keming Zhou*, Wei Zhou, Dongdong Li, Yan Wang, Rongying Zhang and Tao Xu.Differential properties of GTP- and Ca2+-stimulated exocytosis from large dense core vesicles.Traffic. 2006 Apr; 7(4): 416-28.
9. Li CH*, Bai L*, Li DD, Xia S, Xu T. Dynamic tracking and mobility analysis of single GLUT4 storage vesicle in live 3T3-L1 cells. Cell Res. 14(6),(2004),480-6.
联系方式:0551-63607897 baili@ustc.edu.cn
实验室主页:http://en.biox.ustc.edu.cn/Faculty/brjh/201106/t20110620_113986.html