2017.07.03 University of Pittsburgh William R. Stauffer, Ph.D 学术报告会
Frontiers in Biophysics and Neurobiology
报告题目: Cell Type-Specific NHP Optogenetics: Dopamine Neuron Signals for Value and Learning
报告人: William R. Stauffer, Ph.D
Department of Neurobiology
University of Pittsburgh
报告简介：Dopamine neurons synthesize and release dopamine, one of the major modulatory neurotransmitters. These neurons generate phasic responses, short bursts of action potentials, in response to rewards and their predictors. The phasic responses of dopamine neurons code prediction errors. Specifically, these responses scale with the difference in economic value (utility) between received and predicted rewards. Thus, the dopamine prediction error response is directly correlated with the variable used for decision-making. Prediction errors are a natural substrate to support learning and indeed, dopamine prediction error responses develop concomitantly with learning about rewards. In order to establish a causal link between DA and learning, we developed a technique to selectively promote channelrhodopsin expression in non-human primate (NHP) dopamine neurons. We used optical stimulation to drive dopamine neuron action potentials in a pattern similar to phasic responses. Cell type-specific optical stimulation of monkey dopamine neurons produced an effect consistent with the actions of a learning signal, and caused the animals to choose options associated with optical stimulation. This evidence indicates that phasic dopamine responses support value learning, and that dopamine-mediated learning supports economic decision making.