报告题目：Dynamics of function-critical protein states: enzymes, loops, and disordered proteins
报 告 人：Prof. Rafael P. Brüschweiler美国俄亥俄州立大学
邀 请 人：龙冬教授
Prof. Rafael P. Brüschweiler did his Ph.D. under the supervision of Prof. Richard R. Ernst (Nobel Prize in Chemistry, 1991)at ETH (Swiss) and his postdoc at the Scripps Research Institute with Profs. Peter E. Wright (National Academy of Sciences U.S.A., 2008) and David A. Case. Dr. Brüschweiler is nowa tenuredprofessor and Ohio Research Scholar at the Ohio State University and executive director of the CCIC-NMR centre. He has published 193 papers on top journals, including Science, Anal Chem., JACS, JPC, Angew. Chem. et al., and has an h-index of 53.Prof.Brüschweilerhas been long working on the development of new algorithms and their implementation in software or public web servers both in metabolomics and protein NMR.
In this talk, Prof. Brüschweiler will discuss 1) the dynamics of protein states that are critical for their function including the dynamics of arginine kinase along its enzymatic cycle; 2) the effect of nanoparticles on biological systems at the atomic level including how different intrinsically disordered proteins (IDP) interact in specific ways with silica nanoparticles; 3) the dynamics properties of protein loops in globular proteins on multiple timescales and how an increasingly predictive understanding of protein loops can be obtained and how proteins exploit loop dynamics properties at protein-protein interaction interfaces.