报告题目:Inhibitory Circuit Mechanisms for Cortical Activity Dynamics and Plasticity
Diverse types of neurons are interconnected via local or long-range synapses to form specific neural circuits for executing particular brain functions and behaviors. Among the neuron constituents in many circuits, different subtypes of interneuron that releases inhibitory transmitter g-amino butyric acid (GABA) greatly enhance the complexity of circuit architecture and dynamic regulation. In the talk, I would first present our recent findings of differential and cooperative roles of two major inhibitory interneurons, somatostatin (SOM)- and parvalbumin (PV)-expressing cells, in orchestrating diverse oscillatory activities in the cortical circuit. In the second part, I summarize our research findings revealing circuitry bases for the long-standing inhibition gating mechanism that underlies a heightened experience-dependent visual cortical plasticity during a critical period over the postnatal development.