生命科学讲坛：2018.09.07 Dhan V. Kalvakolanu教授（马里兰大学）学术报告会
报告题目：Endoplasmic reticulum and Cancer 报告人：Dhan V. Kalvakolanu 教授（马里兰大学）
时间：2018年9月7日 9：00-10：00 地点：429会议室 联系人：肖卫华（63600536） 报告人简介：Dr. Kalvakolanu has extensive experience in the areas of molecular biology, Cancer Biology, Virology, cytokine induced innate immunity, Signal transduction, autophagy, apoptosis, and transcriptional regulation of gene expression. His seminal contributions include the discovery of GRIMs, a novel group of tumor suppressor genes; novel cytokine inducible gene regulatory elements, their cognate transcription factors and signal transduction pathways that control them. He is also one of the first few investigators who described mechanisms of how viral oncogenes resist Interferon actions. His work centers on the regulation of novel cell death-activating genes and how aberrations in these gene products influence tumor development and metastasis. Regulation of gene transcription and signal transduction by cytokines and chemokines, e.g. JAK-STAT, MAPK C/EBP, AP1 and ATF signaling pathways. The roles of endoplasmic reticulum in suppressing tumor cell growth, promoting Apoptosis and autophagy. Their lab is engaged in defining how cytokines exert direct tumor suppressive actions on tumor cells. In particular, they were interested in defining combinations of other drugs that would exert synergistic antitumor actions when combined with Interferons. Immune escape is a major contributor to tumor metastases.