教授 博士生导师 2000年在中国科学技术大学生命科学学院获得本科学位 2005年在中国科学技术大学生命科学学院获得博士学位 2006-2008年在美国Mayo Clinic作博士后 2009-2015年在多伦多大学结构基因组联盟从事真核基因转录调控和RNA修饰的结构生物学研究
已发表文章60多篇，总引用2500多次(Web of Science)。其中>20篇为第一作者（含共同第一作者）或通讯作者，发表在Cell，Nature Chemical Biology, Nature Structural & Molecular Biology, Cell Research, Genes & Development, Nature Communications, PNAS, EMBO Journal, Science Signaling，eLife等国际一流期刊上。
主要研究兴趣：运用X-射线晶体衍射以及核磁共振等工具，结合分子生物学，生物物理学以及化学生物学等手段，研究真核生物中生物大分子化学修饰,包括蛋白质翻译后修饰与核酸修饰产生、消除和识别的分子机制，以及这些修饰异常的致病（肿瘤和神经退行性疾病等）机理。并通过化学小分子筛选辅助药物设计达到控制或者治疗疾病的目的，积极推进结构生物学向疾病治疗方向的转化。
联系方式： E-mail: xuchaor@ustc.edu.cn
ResearcherID: http://www.researcherid.com/rid/G-3885-2010
近期代表论文（*:通讯作者; #:共同第一作者）：
2016年加入中国科学技术大学以后 (含2016):
1. #Chen, X., #Liao, X., #Makaros, Y., Guo, Q., Zhu, Z., Krizelman, R., Dahan, K., Tu, X., Yao, X., *Koren, I., *Xu, C. Molecular basis for arginine C-terminal degron recognition by Cul2FEM1 E3 ligase. Nat. Chem. Biol. (2020). (In press).
2. #Liao, S., #Rajendraprasad, G., #Wang, N., Eibes, S., Gao, J., Yu, H., Wu, G., Tu, X., *Huang, H., *Barisic, M. *Xu, C. Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis. Cell Res. 29, 533-547. (2019).
3. #Zeng, C., #Weng, C., #Wang, X., #Yan, Y., Li, W., Xu, D., Hong, M., Liao, S., Dong, M., *Feng, X., *Xu, C., *Guang, S. Functional proteomics identified a PICS complex required for piRNA maturation and chromosome segregation. Cell. Rep. 27, 3561-3572.e3 (2019).
4. #Guo, Q., #Liao, S.,#Kwiatkowski, S., Tomaka, W., Yu, H., Wu, G., Tu, X., Min, J., *Drozak, J., *Xu, C. Structural insights into SETD3-mediated histidine methylation on β-actin. eLife 8, e43676. (2019).
5. Liao, S., *Sun, H., *Xu, C. YTH Domain: A Family of N6-methyladenosine (m6A) Readers. Genomics, Proteomics & Bioinformatics.16, 99-107. (2018).
6. *Xu, C., Ishikawa, H., Izumikawa, K., Li, L., He, H., Nobe, Y., Yamauchi, Y., Shahjee, M.H., Xian-Hui Wu, Yu, Y., Isobe, T., Takahashi, N., *Min, J. Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev. 30, 2376-2390. (2016).
7. #Chung, H., #Xu, C., #Fuchs, A.,Mund, A.,Lange, M.,Steage, H.,Schubert, T.,Bian, C.,Dunkel, I., Eberharter, A., Regnard, C.,Klinker, H.,Meierhofer, D.,Cozzuto,L., Winterpacht, A., Di Croce, L., Min, J., Will, H., *Kinkley, S. PHF13 is a Molecular Reader and Transcriptional Co-Regulator of H3K4me2/3. eLife 5, e10607. (2016).
2016年以前：
8. *#Xu, C., #Wang, X., #Liu, K., Roundtree, I., Tempel, W., Li, Y., Lu, Z., *He, C., *Min, J. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain. Nat. Chem. Biol. 10, 927-929. (2014). (Recommended by Faculty of 1000).
9. #Ni, Z., #Xu, C., Guo, X., Hunter, G., Kuznetsova, O., Tempel, W., Marcon, E., Zhong, G., Guo, H., Kuo, W., Li, J., Young, P., Olsen, J., Wan, C., Loppnau, P., Bakkouri, M., Senisterra, G., He, H., Huang, H., Sidhu, S., Emili, A., Murphy, S., Mosley, A.,Arrowsmith, C., *Min, J., *Greenblatt, J.RPRD1A and RPRD1B Serve as RNAPolymerase II Carboxyl-Terminal Domain Scaffolds to Recruit RPAP2 for Serine 5 Dephosphorylation. Nat. Struct. Mol. Biol. 21, 686-695. (2014).
10. #Xu, Y., #Xu, C., #Kato, A., Tempel, W., Abreu, J.C., Bian, C.,Hu, Y., Hu, D., Zhao, B., Cerovina, T., Diao, J., Wu, F., He, H.H., Cui, Q., Clark, E., Ma, C., Barbara, A., Veenstra, G.J.C., Xu, G., Kaiser, U.B., Liu, X.S., Sugrue, S.P., He, X., *Min, J., *Kato, Y., *Shi, Y.G. Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for XenopusEye and Neural Development. Cell 151, 1200-1213. (2012).
11. #Xu, C., #Jin, J., Bian, C., Lam, R., Tian, R., Weist, R., You, L., Nie, J., Bochkarev, A., Tempel, W., Tan, C., Wasney, G., Vedadi, M., Gish, G., Arrowsmith, C., Pawson, T., Yang, X., *Min, J. Sequence-specific Recognition of a PxLPxI/L Motif by the Ankyrin-repeat Tumbler Lock. Sci. Signal. 5, ra39. (2012).
12. #Bian, C., #Xu,C., #Ruan, J., #Lee, K., #Burke, T., Tempel, W., Barsyte, D., Li, J., Wu, M., Zhou, B., Fleharty, B.E., Paulson, A., Allali-Hassani, A., Zhou, J., Mer, G., Grant, P., *Workman, J.L., *Zang, J., *Min, J. Structural Basis of Sgf29 Tandem Tudor Domains Selectively Binding Methylated Histone H3K4 to Regulate Enzymatic Activity of the SAGA Complex. EMBO J. 30, 2849-2842. (2011).
13. #Xu, C., #Bian, C., Lam, R., Dong, A. *Min, J. Structural Basis of Selective Binding of Nonmethylated CpG islands by the CXXC Domain of CFP1. Nat. Commun. 2: 227. (2011).
14. #Xu, C., #Bian, C., #Yang, W., Galka, M., Ouyang, H., Chen, C., Qiu, W., Liu, H., Jones, A., MacKenzie, F., Pan, P., *Li, S., *Wang, H., *Min, J. Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc. Natl. Acad. Sci. 107, 19266-19271. (2010).