报告题目：Understanding epigenetics in a protein family approach and its application to drug development
报告人： 闵金荣 教授
邀请人： 许超 教授
报告摘要：The basic subunit of chromatin is the nucleosome, consisting of 147 base pairs of DNA wrapped around an octamer of core histone proteins. Both histones and DNA can be modified, and these chromatin modifications are dynamic. Chromatin-modifying enzymes (“writer” and “eraser”) and modification recognition proteins (“reader”) comprise the main components of chromatin signalling. Chromatin signalling is a complex system of communications that governs activities of nuclear proteins and actively regulates gene expression plus many other key biological processes. Dysregulation of chromatin signalling can result in pathogenesis of cancers and other genetic diseases.My laboratory uses the technique of structural biology in combination with other biochemical and biophysical methods to systematically study epigenetic proteins in a protein family approach in order to understand the specificity/selectivity, and division of labor in the cell of these epigenetic protein families, and this piece of information would be essential in designing target-specific drugs and annotating the potential functions of those function-unknown proteins. In this talk, I am going to present some examples on how we characterize methylation “reader” protein families using this approach and its application to the development of chemical probes and medicines.