主要研究方向：

1.研究由lncRNA和三维基因组空间结构组成的三维空间转录调控在脑衰老中的作用

2.研究lncRNA和染色质相互作用在减数分裂和精子发生过程中的转录调控作用

教授 博士生导师 毕业于北京师范大学生物系 1996年和1999年分别获得学士和硕士学位 2006年在美国罗彻斯特大学生物系取得分子、细胞和发育生物学博士学位 2006-2012年在加州大学圣地亚哥分校进行博士后研究 期间获得癌症研究所博士后奖学金资助。2012年12月加入中国科学技术大学生命科学学院。多年来一直从事基因转录调控、长链非编码RNA（lncRNA）、三维基因组空间结构等相关研究，在Genome Research、Cell Death Differentiation、Genes Development、Nucleic Acids Research等学术期刊上发表了系列文章。

代表性学术论文:

1. Cheng Q., Zhao W., Song X.^*, Jin T.^* Machine-learning and scRNA-Seq-based diagnostic and prognostic models illustrating survival and therapy response of lung adenocarcinoma. Genes and Immunity. 2024, Jul 29. doi: 10.1038/s41435-024-00289-0. Epub ahead of print.

2. Wang Q.^#, Chen P.^#, Wang X.^#, Wu Y., Xia K., Mu X., Xuan Q., Xiao J., He Y., Liu W., Song X.^*, Sun F^*. piR-36249 and DHX36 together inhibit testicular cancer cells progression by upregulating OAS2. Noncoding RNA Research. 2023, 8(2):174-186.

3. Luo Z.^#, Zhang R.^#, Hu T.^#, Zhu Y., Wu Y., Li W., Zhang Z., Yao X., Liang H., Song X.^*. NicE-C efficiently reveals open chromatin-associated chromosome interactions at high resolution. Genome Research. 2022, Feb 1: gr.275986.121. doi: 10.1101/gr.275986.121. Online ahead of print. ^*Corresponding author.

4. Wang F.^#, Wang Q.^#, Liu B.^#, Mei L., Ma S., Wang S., Wang R., Zhang Y., Niu C., Xiong Z., Zheng Y., Zhang Z., Shi J., Song X.^*. The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum. Cell Death & Differentiation. 2021, 28(9):2634-2650. ^*Corresponding author.

5. Cheng Q., Wu Y, Xia H.^*, Song X.^*. RGL2 as an age-dependent factor regulates colon cancer progression. Computational and Structural Biotechnology Journal. 2021, 19: 2190-2201. ^*Corresponding author.

6. Luo Z.^*#, Hu T. ^*, Jiang H., Wang R., Xu Q., Zhang S., Cao J., Song X.^*. Rearrangement of macronucleus chromosomes correspond to TAD-like structures of micronucleus chromosomes in Tetrahymena thermophila. Genome Research. 2020. Mar 12. 30(3):406-414. ^*Corresponding author. 

7. Luo Z.^#, Wang X.^#, Jiang H.^#, Wang R.^#, Chen J., Chen Y., Xu Q., Cao J., Gong X., Wu J., Yang Y., Li W., Han C., Cheng YC., Rosenfeld MG., Sun F.^*, Song X.^*. Reorganized 3D genome structures support transcriptional regulation in mouse spermatogenesis. iScience. 2020, 23(4): 101034. ^*Corresponding author.

8. Ghanam AR., Cao J., Ouyang X., and Song X.^*. New insights into chronological mobility of retrotransposable elements in vivo. Oxidative Medicine and Cellular Longevity. 2019. 2818415. eCollection 2019. ^*Corresponding author.

9. Wang F.^#, Ren D.^#, Liang X.^#, Ke S., Zhang B., Hu B.^*, Song X.^*, Wang X.^*. A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic Acids Research. 2019, 47(12): 6315-6329. ^*Corresponding author.

10. Xu Q.^#, Wang R.^#, Ghanam AR., Yan G., Miao W., Song X.^*. The key role of CYC2 during meiosis in Tetrahymena thermophila. Protein & Cell. 2016, 7(4):236-49. ^*Corresponding author.

11. Cao J., Luo Z., Cheng Q., Xu Q., Zhang Y., Wang F., Wu Y., Song X.^*. Three-dimensional regulation of transcription. Protein & Cell. 2015, 6(4):241-53. ^*Corresponding author.

12. Song X., Bowen J., Miao W., Liu Y., and Gorovsky MA.^*. The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation. Genes & Development. 2012, 26(6):615-29. ^*Corresponding author.

13. Song X.^#, Wang X.^#, Arai S. and Kurokawa R.^*. Promoter-associated noncoding RNA from the CCND1 promoter. Methods in Molecular Biology. 2012, 809:609-22. ^#Co-first author.

14. Harismendy O.^#, Notani D.^#, Song X., Rahim NG., Tanasa B., Heintzman N., Ren B., Fu XD., Topol EJ., Rosenfeld MG^*, and Frazer KA^*. 9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature. 2011, 470(7333):264-8. ^#Co-first author.  

15. Wang X.^# and Song X.^#, Glass CK., and Rosenfeld MG*. The Long Arm of Long Noncoding RNAs: Roles as Sensors Regulating Gene Transcriptional Programs. Cold Spring Harb Perspect Biol. 2011, 3(1):a003756. ^#Co-first author. Collected in《The RNA World》IV. ^#Co-first author

16. Wang X., Arai S.^%, Song X.^%, Reichart D., Du K., Pascual G., Tempst P., Rosenfeld MG.^#, Glass CK.^#, and Kurokawa R.^#. Induced ncRNAs allosterically modify RNA binding proteins in cis to inhibit transcription. Nature. 2008, 454(7200):126-30. ^%Co-second author 

17. Song, X.^#, Gjoneska E.^#, Ren Q.^#, Taverna SD., Allis C.D., and Gorovsky MA.^*. Phosphorylation of the SQ H2A.X motif is required for proper meiosis and mitosis in Tetrahymena thermophila. Mol Cell Biol. 2007, 27(7):2648-60. ^*Co-first author. 

18. Song X. and Gorovsky MA.^*. Unphosphorylated H1 is enriched in a specific region of the promoter when CDC2 is down-regulated during starvation. Mol Cell Biol. 2007, 27(5):1925-33.

19. Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., and Gorovsky MA.^*. A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. PNAS. 2002, 99(6):3734-9.

实验室招聘实验员、硕博研究生和本科实习生。同时招聘具有分子生物学及生物信息学等相关背景的博士后，待遇从优。

联系方式： E-mail:songxy5@ustc.edu.cn.

电话：63607752.

ResearcherID :http://www.researcherid.com/rid/P-1094-2014