赵忠

主要研究兴趣：

位于顶端分生组织中的干细胞是植物胚后发育所有器官的来源，干细胞对环境的响应是植物适应环境变化可塑性发育的核心。赵忠教授主要进行以下几方面的研究：

1）植物干细胞维持与分化调控的信号和分子机制。

2）干细胞如何响应环境信号调控植物的可塑性发育。

3）探索基于植物干细胞的生物技术。

博士，教授，博导。中国科学技术大学生命科学与医学部副部长，国家基金委创新研究群体项目负责人（2024）。中国细胞生物学会常务理事，中国植物生理与植物分子生物学会理事，中国科学院分子植物科学卓越创新中心研究员，安徽省植物学会副理事长，安徽省细胞生物学会常务理事，2015-2019年中国细胞生物学会植物器官发生分会会长，教育部大学生物学课程教学指导委员会委员。

教育和研究经历：

1991年和1994年毕业于兰州大学生物系细胞生物学专业，分别获理学学士和硕士学位。2003年毕业于复旦大学生化系，获理学博士学位。2003－2005年赴法国国家科研中心（CNRS）植物分子生物学研究所（IBMP）从事博士后研究。2006－2009年，在德国马普（Max Planck）发育生物研究所从事博士后研究。2009－2011年，在海德堡大学干细胞生物学系工作。2011年至今任中国科技大学生命科学学院教授、讲席教授。

长期从事植物干细胞和发育生物学研究，解析了干细胞中生长素和细胞分裂素互作的分子机制(Nature, 2010)；发现了干胞中 WUSCHEL介导的广谱抗病毒机制(Science, 2020)，不仅回答了为什么植物病毒不能侵染植物分生组织这一长期未决的生物问题，同时也为培育广谱抗病毒作物提供了新的思路；揭示了活性氧等逆境信号分子控制干细胞微环境的分子机制(EMBO J, 2017; Nature Plants, 2021)；解析了生长素在调控干细胞维持与分化过程中信号输出稳定性的机制。(Mol Plant., 2018，PNAS, 2023)；首次在高等生物中揭示了组蛋白 H3 第 36 位赖氨酸甲基化的生物学功能(Nature Cell Biology, 2005)。在Nature，Science，Nature Cell Biology, Nature Plants等学术期刊发表论文30 余篇，其中 7 篇受到 Faculty Opinions (F-1000)推荐、1 篇为 ESI 高被引论文。研究成果 2021 年被评为中国农业科学(十项)重大进展。

论文发表统计:

Scopus: https://www.scopus.com/authid/detail.uri?authorId=55726118900

Researchgate：https://www.researchgate.net/profile/Zhong_Zhao13

代表性学术论文:

Li J, Zeng J, Tian Z, Zhao Z. Root-specific photoreception directs early root development by HY5-regulated ROS balance. Proc. Natl. Acad. Sci. U. S. A. 121, e2313092121, 2024.

Dai, Y., Luo, L. and Zhao, Z. Genetic robustness control of auxin output in priming organ initiation. Proc. Natl. Acad. Sci. U. S. A. 120, e2221606120, 2023.

Zeng J, Li X, Ge Q, Dong Z, Luo L, Tian Z, Zhao Z. Endogenous stress-related signal directs shoot stem cell fate in Arabidopsis thaliana. Nature Plants. 7: 1276–1287, 2021.

Wu H, Qu X,Dong Z, Luo L, Shao C, Forner J, Lohmann JU, Su M, Xu M, Liu X, Zhu L, Zeng J, Liu S, Tian Z, Zhao Z. WUSCHEL triggers innate antiviral immunity in plant stem cells. Science. 370(6513): 227-231, 2020.

Zhong P, Li J, Luo L, Zhao Z, Tian Z. Top1α regulates FLOWERING LOCUS C expression by coupling histone modification and transcription machinery. Development. doi:10.1242/dev.167841. 2019.

Yang L, Wang HN, Hou XH, Zou YP, Han TS, Niu XM, Zhang J, Zhao Z, Todesco M, Balasubramanian S, Guo YL.Parallel Evolution of Common Allelic Variants Confers Flowering Diversity in Capsella rubella. Plant Cell. 30(6): 1322-1336, 2018.

Luo L, Zeng J, Wu H, Tian Z, Zhao Z. A Molecular Framework for Auxin-Controlled Homeostasis of Shoot Stem Cells in Arabidopsis. Molecular Plant. 11(7), 899-913, 2018.

Qu X, Zhao Z and Tian Z.ERECTA regulates cell elongation by activating auxin biosynthesis in Arabidopsis thaliana. Front. Plant Sci. doi: 10.3389/fpls.2017.01688, 2017.

Zeng J, Dong Z, Wu H, Tian Z, Zhao Z.Redox regulation of plant stem cell fate.EMBO J. 36, 2844-2855, 2017.

Yang ZB, Liu G, Liu J, Zhang B, Meng W, Müller B, Hayashi KI, Zhang X, Zhao Z, De Smet I, Ding Z. Synergistic action of auxin and cytokinin mediates aluminum-induced root growth inhibition in Arabidopsis. EMBO reports. 18(7): 1213-1230, 2017.

Wang J, Tian C, Zhang C, Shi B, Cao X, Zhang TQ, Zhao Z, Wang JW, Jiao Y. Cytokinin Signaling Activates WUSCHEL Expression during Axillary Meristem Initiation. Plant Cell. 29(6): 1373-1387, 2017

Cui Y, Rao S, Chang B, Wang X, Zhang K, Hou X, Zhu X, Wu H, Tian Z, Zhao Z, Yang C, Huang T. AtLa1 protein initiates IRES-dependent translation of WUSCHEL mRNA and regulates the stem cell homeostasis of Arabidopsis in response to environmental hazards. Plant Cell Environ. 38(10) :2098-2114, 2015.

Somorjai IM, Lohmann JU, Holstein TW, Zhao Z. Stem cells: a view from the roots. Biotechnol J. 7(6): 704-22, 2012.

Zhao Z, Andersen SU, Ljung K, Dolezal K, Miotk A, Schultheiss SJ and Lohmann JU. Hormonal control of the shoot stem cell niche. Nature, 465: 1089-1092, 2010.

BuschW,MiotkA,ArielFD,Zhao Z, Forner J,Daum G,SuzakiT,Schuster C Schultheiss SJ, Leibfried A,Haubeiß S, Ha N, Chan R and LohmannJU. Transcriptional control of a plant stem cell niche.Developmental Cell. 18, 841-853, 2010.

Buechel S, Leibfried A, To JP, Zhao Z, Andersen SU, Kieber JJ, Lohmann JU. Role of A-type ARABIDOPSIS RESPONSE REGULATORS in meristem maintenance and regeneration. Eur J Cell Biol. 89(2-3): 279-84, 2010

Zhao Z, Zhu Y, Erhardt M, Ruan Y, Shen WH. A Non-canonical Transferred DNA Insertion at the BRI1 Locus in Arabidopsis thaliana. J Integr Plant Biol., 51(4): 367-73, 2009.

Andersen SU, Buechel S, Zhao Z, Ljung K, Novák O, Busch W, Schuster C, Lohmann JU. Requirement of B2-type cyclin-dependent kinases for meristem integrity in Arabidopsis thaliana. Plant Cell, 20(1): 88-100, 2008.

Xu L, Zhao Z, Dong A, Soubigou-Taconnat L, Renou JP, Steinmetz A, Shen WH. Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis haliana. Mol Cell Biol., 28(4): 1348-60, 2008.

Feng X, Zhao Z, Tian Z, Xu S, Luo Y, Cai Z, Wang Y, Yang J, Wang Z, Weng L, Chen J, Zheng L, Guo X, Luo J, Sato S, Tabata S, Ma W, Cao X, Hu X, Sun C, Luo D. Control of petal shape and floral zygomorphy in Lotus japonicus. Proc Natl Acad Sci U S A. 103(13): 4970-4975, 2006 (co-first authors).

Guo X, Zhao Z, Chen J, Hu X, Luo D. A putative CENTRORADIALIS/TERMINAL FLOWER 1-like gene, Ljcen1, plays a role in phase transition in Lotus japonicus. J Plant Physiol., 163(4): 436-44, 2006.

Zhao Z, Yu Y, Meyer D, Wu C and Shen WH. Prevention of early flowering by expression of FLOWERING LOCUS C requires methylation of histone H3 K36. Nature Cell Biology, 7(12): 1256-60, 2005.

Dong ZC, Zhao Z, Liu CW, Luo JH, Yang J, Huang WH, Hu XH, Wang TL, Luo D. Floral patterning in Lotus japonicus. Plant Physiol., 137(4): 1272-82, 2005.

Luo JH, Yan J, Weng L, Yang J, Zhao Z, Chen JH, Hu XH, Luo D. Different expression patterns of duplicated PHANTASTICA-like genes in Lotus japonicus suggest their divergent functions during compound leaf development. Cell Res. 2005, 15(8): 665-77, 2005.

Zhao Z and Shen WH. Plants contain a high number of proteins showing sequence similarity to the animal SUV39H family of histone methyltransferases. Ann.N.Y.Acad.Sci.1030: 661-669, 2004.

Hu.W, Zhang, S., Zhao Z, Sun. C., Zhao. Y. and Luo. D. The analysis of the structure and expression of OsTB1 gene in rice. Journal of Plant Physiology and Molecular Biology, 29(6): 507-514, 2003

Zheng LY, Zhu XD, Qian Q, Zhao Z, Zhang JJ, Hu XH, Lin HX and Luo D, Morphological and gene location analysis on rice cl mutant. Chinese Science Bulletin, 48(3): 264-267, 2003

Zhao Z and Jia J-F.Selection of methionine-resistance variant of Medicago sativa. Acta Botanica Sinica. 39(10): 933-939, 1997

Zhao Z and Jia J-F. Selection of methionine-resistance variant of Onobrychis viciaefolia Scop. Acta Botanica Sinica. 38(4): 268-275, 1996

Zhao Z, Lin H and Jia J-F. The accumulation of organic osmotica of the salt-tolerant calli under the NaCl stress in Onobrychis viciaefolia. Journal of Lanzhou University (Nature Sciences). 30(suppl.): 36-39, 1994

Zhao Z and Jia J-F.Selection of NaCl-tolerant cell line of Medicago sativa and Onobrychis viciaefolia and analysis of their physiological and biochemical characteristics. Journal of Lanzhou University (Nature Sciences). 28(3): 109-114, 1992

联系方式：

电话：0551-63600640

传真：0551-63600640

Email：zhzhao@ustc.edu.cn

招生招聘：

1，本科实习生、研究生：对发育生物学和植物学感兴趣。