丁勇

主要研究兴趣:

环境温度决定植物开花时间的分子机制

组蛋白修饰建立和维持的分子机制

中国科学技术大学生命科学院教授、博士生导师。海外高层次人才引进计划入选者、科技部“中青年创新领军人才” 入选者、国家高层次人才特殊支持计划科技创新领军人才。

2007年获中国科学院遗传与发育生物学研究所博士学位；2007-2010年分别在西南医学中心和内布拉斯加大学从事博士后研究工作；2011年1月-2012年8月在内布拉斯加大学任研究助理教授(Research Assistant Professor)；2012年9月入选海外高层次人才引进计划任职教授至今。

开花时间决定植物能否成功繁衍下一代和作物的产量。丁勇研究组长期从事植物开花时间的表观调控机制研究，自2012年回国建立实验室以来，系统解析了植物组蛋白H3第4位赖氨酸三甲基化(H3K4me3) 有别于哺乳动物的独特调控方式；发现了植物组蛋白特有的H2A第95位丝氨酸磷酸化(H2AS95ph) 修饰及其调控的全新机制；首次报道植物“干旱记忆”和“转录记忆”及其表观调控；揭示了长非编码RNA调控组蛋白27位赖氨酸三甲基化(H3K27me3) 的内在机制；发现了植物的糖与光照条件下诱导的组蛋白H3第11位磷酸化促进基因转录的机制。上述研究延伸并拓展了组蛋白修饰的生物学内涵，揭示了植物组蛋白修饰位点和调控方式的独特性，提示了植物组蛋白修饰研究的重要性和必要性。相关研究成果发表在Nature Plants, Science Advances、The Plant Cell、PNAS、Nature Communications等学术期刊上，多篇文章被Faculty 1000推荐，以及被Cell和Plant Cell等杂志评述。

主持基金委重点项目、重大项目、面上项目以及中科院战略先导项目多项，现任中国遗传学会理事、中国遗传学会表观遗传分会委员、中国细胞学会染色体分会委员、中国生理与生化学会细胞生物学分会委员、安徽省遗传协会副会长。

课题组学生所获奖励：

2020年博士生田永科获得中国科学院院长优秀奖

2019年博士生田永科获得研究生国家奖学金

2019年博士生田永科获得鸿翼植物科学奖学金一等奖

2019年博士生田永科获得中国科学技术大学“2019年博士论文创优计划” 资助

2019年博士生张飞获得鸿翼植物科学奖学金三等奖

2019年博士生郑撼获得中国科学院院长优秀奖

2019年博士生郑撼获得鸿翼植物科学奖学金二等奖

2019年博士生郑撼获得优秀博士论文提名奖

2018年博士生郑撼获得研究生国家奖学金

2018年博士生苏艳华获得中国科学院院长优秀奖

2017年博士生苏艳华获得研究生国家奖学金

2015年博士生田永科获得光华奖学金

2015年硕士生张飞获得光华奖学金

2014年硕士生苏艳华获得光华奖学金

论文发表统计表链接:

Google Scholar: https://scholar.google.com/citations?user=v7mclSoAAAAJ&hl=zh-CN

Researchgate：https://www.researchgate.net/lab/Yong-Dings-lab-Yong-Ding

回国后研究论文（通讯作者）：

1. Hu P, Xu Y, Su Y, Wang Y, Xiong Y, and and Ding Y^*. Nuclear-localized pyruvate kinases control phosphorylation of histone H3 on threonine 11. Nature Plants. 2024 (in press).

2. Lu Q, Shi W, Zhang F^#, and Ding Y^*. ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis. Plant Journal. 2024 Mar 6.

3. Yang Y^#, Zhang C^#, Li H^#, Yang Z, Xu Z, Tai D, Ni D, Wei P, Yi C, Yang J, and Ding Y^*An epi-allele of SMS causes Sanming dominant genic male sterility in rice. 2023. 66 (12) :2701-2710. Science China Life Science (Cover story).

4. ChenL^#, Hu P^#, LuQ, Zhang F, SuY, and Ding Y^*. Vernalization attenuates dehydration tolerance in winter-annual Arabidopsis. Plant Physiology. 2022.190(1):732-744.

5. Xu Z, Li E, Xue G, Zhang C, Yang Y, and Ding Y^*. OsHUB2 inhibits function of OsTrx1 in heading date in rice. Plant Journal. 2022. 110(6):1670-1680.

6. Ikram A,^# Zhang F^#, Wang S, Su Y, and Ding Y^*. Chromatin remodeling factors OsYAF9 and OsSWC4 interact to promote internode elongation in rice. Plant Physiology. 2022 188(4):2199-2214.

7. Wang S^#, Zhang F^#, Jiang P, Zhang H, Zheng H, Chen R, Xu Z, Ikram A, Li E, Xu Z,Fan J, Su Y^*, and Ding Y^*.SDG128 is involved in maize leaf inclination. Plant Journal. 2021 108(6):1597-1608.

8. Huang T^#, Zhang H^#, Zhou Y, Su Y, Zheng H^*, and Ding Y^*. Phosphorylation of Histone H2A at Serine 95 Is Essential for Flowering Time and Development in Arabidopsis. Frontiers in Plant Science. 2021 Nov 23;12:761008.

9. Yang Y, Li J, Li H, Xu Z, Qin R, Wu W, Wei P, Ding Y^*. Yang, J^*. SDF5 encoding P450 protein is required for internode elongation in rice. Rice Science. 2021 28 (4): 313-316.

10. Tiang Y^#, Zheng H^#, Zhang F^#, Wang S, Ji X, Xu C, He Y, Ding Y^*. PRC2 recruitment and H3K27me3 deposition at FLC require FCA binding of COOLAIR. Science Advances. 2019 24; 5 (4): eaau7246.

F1000 comments: https://f1000.com/prime/735606638

11. Jiang P, Wang S, ZhengH, Li H, Zhang F, Su Y , Xu Z, Lin H , Qian Q, Ding Y^*. SIP1 participates in regulation of flowering time in rice by recruiting OsTrx1 to Ehd1. New Phytologist. 2018. 219(1): 422-435.

12. Jiang P, Wang S, Jiang H, Cheng B, Wu K, Ding Y^*. The COMPASS-like complex promotes flowering and panicle branching in rice. Plant Physiology. 2018. 176 (4): 2761-2771.

13. Jiang P, Wang S, Ikram A, Xu Z Jiang H, Cheng B^*, Ding Y^*.SDG721 and SDG705 are required for rice growth. Journal of Integrative Plant Biology.2018. 60 (7): 530-535. (Cover story)

14. Zheng H, Zhang F, Wang S,Su Y, Ji X, Jiang P, Chen R, Hou S, Ding Y*.MLK1 and MLK2 coordinate RGA and CCA1 activity to regulate hypocotyl elongation in Arabidopsis thaliana. Plant Cell. 2018 30 (1): 67-82.

15. Su Y, Wang S, Zhang F, Zheng H, Liu Y, Huang T, Ding Y^*. Phosphorylation of histone H2A at serine 95: A plant-specific mark involved in flowering time regulation and H2A.Z deposition. Plant Cell.2017 29 (9): 2197-2213.

Highlighted in Brief: Know Your histone (zip) code: flowering time and phosphorylation of histone H2A on serine 95. Plant Cell. 2017 29 (2): 2084-2085.

16. Lu C^#, Tian Y^#, Wang S, Su Y, Mao T, Huang T, Chen Q, Xu Z, Ding Y^*. Phosphorylation of SPT5 by CDKD;2 is required for VIP5 recruitment and normal flowering in Arabidopsis thaliana. Plant Cell. 2017 29 (2): 277-291.

17. Ding Y, Virlouvet L, Liu N, Riethoven JJ, Fromm M, Avramova Z. Dehydration stress memory genes of Zea mays; comparison with Arabidopsis thaliana. BMC Plant Biololgy. 2014 14: 141.

18. Ding Y, Liu N, Virlouvet L, Riethoven JJ, Fromm M, Avramova Z. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biololgy. 2013 13: 229.

19. Song Z, Sun L, Lu S, Tian Y, Ding Y, Liu J. Transcription factor interaction with COMPASS-like complex regulates histone H3K4 trimethylation for specific gene expression in plants. PNAS. 2015 112 (9): 2900-5.

20. Virlouvet L, Ding Y, Liu N, Avramova Z, Fromm M. ABA Signaling is necessary but not sufficient for RD29B transcriptional memory during successive dehydration stresses in Arabidopsis thaliana. The Plant Journal. 2014 79 (1): 150-61.

21. Liu N, Ding Y, Fromm M, Avramova Z. Different gene-specific mechanisms determine the ‘revised-response’ memory transcription patterns of a subset of A. thaliana dehydration stress responding genes. Nucleic Acids Research. 2014 42 (9): 5556-66.

22. Ding Y, Ndamukong I, Xu Z, Lapko H, Fromm M, Avramova Z. ATX1-generated H3K4me3 Is required for efficient elongation of transcription, not Initiation, at ATX1-regulated genes. PLoS Genetics. 2012 8 (12): e100311.

回国之前发表的部分主要论文

23. Ding Y, Fromm M, Avramova Z. Multiple exposures to drought 'train' transcriptional responses in Arabidopsis.Nature Communications. 2012 13 (3): 740.

F1000 comments: http://f1000.com/14267187

24. Ding Y, Ndamukong I, Zhao Y, Xia Y, Riethoven JJ, Jones DR, Divecha N, Avramova Z.Divergent functions of the myotubularin (MTM) homologs AtMTM1 and AtMTM2 in Arabidopsis thaliana: evolution of the plant MTM family.The Plant Journal. 2012; 70 (5): 866-78.

25. Ding Y, Avramova Z, Fromm M. The Arabidopsis Trithorax-like factor ATX1 functions in dehydration stress responses via ABA-dependent and ABA-independent pathways. The Plant Journal 2011 66 (5): 735-44.

26. Ding Y, Avramova Z, Fromm M. Two distinct roles of Arabidopsis homolog of Trithorax (ATX1), at promoters and within transcribed Regions of ATX1 regulated Genes. The Plant Cell 2011 23 (1): 350-63.

F1000 comments: https://f1000.com/prime/9929957.

27. Ding Y, Wang X, Su L, Zhai J, Cao S, Zhang D, Liu C, Bi Y, Qian Q, Cheng Z, Chu C, Cao X. SDG714, a histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. The Plant Cell, 2007 19 (1): 9-22.

Comments: Connecting the dots between histone methylation and DNA methylation. Cell 2007 128 (3): 633.

招生招聘:

欢迎有志于植物组蛋白表观遗传学和植物开花时间，以及环境适应性的优秀学子加入，同时热忱欢迎对本实验室研究方向感兴趣的本科生前来攻读博士学位。实验室招聘助研（副研），常年招收博士后和客座学生。

联系方式： Email:dingyong@ustc.edu.cn

电话：0551-63601337