博士生导师,入选国家海外高层次人才青年项目。2012年毕业于中国科学技术大学获得博士学位。2013至2017年先后在美国斯坦福大学医学院分子和细胞生理学系(2013-2016)和加拿大多伦多大学Donnelly Centre(2016-2017)进行博士后研究。多年来,一直从事蛋白质复合物、膜蛋白的结构与功能研究,并开发新型蛋白质工程方法用于抗体筛选、蛋白质活性改造和细胞信号通路调控等。研究成果主要发表于Nature、Nature Chemical Biology、 PNAS、eLife等国际学术期刊。
主要研究方向:
1. 膜蛋白结构与功能研究。利用结构生物学研究方法,阐述高等生物跨膜蛋白介导物质转运和信号转导的分子机制。
2. 抗体设计与蛋白质工程改造。设计抗体、蛋白质文库并筛选具有所需活性的蛋白变体,用于基础研究和药物开发。
3. 合成生物学。以哺乳动物细胞为底盘,设计正交信号通路,用于智能细胞设计和改造,达到针对特定疾病的精准治疗。
代表性论文 (*First author, #Corresponding author):
1. Guo Q, He B, Zhong Y, Jiao H, Ren Y, Wang Q, Ge Q, Gao Y, Liu X, Du Y, Hu H, Tao Y. (2023) A method for structure determination of GPCRs in various states. Nature Chemical Biology doi 10.1038/s41589-023-01389-0
2. Zhou J, Ge Q, Wang D, Guo Q, Tao Y. (2023) Engineering a modular double-transmembrane synthetic receptor system for customizing cellular programs. Cell Rep 42:112385
3. Ge Q, Teng M, Li X, Guo Q, Tao Y. (2023) An epitope-directed selection strategy facilitating the identification of Frizzled receptor selective antibodies. Structure 31:33-43.
4. Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y. (2022) Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Nature Communications 13:454
5. Wang M, Guo Q, Zhu K, Fang B, Yang Y, Teng M, Li X, Tao Y. (2020) Interface switch mediates signal transmission in a two-component system. PNAS 117:30433-30440
6. Zhao D, Liu L, Liu X, Zhang J, Yin Y, Luan L, Jiang D, Yang X, Li L, Xiong H, Xing D, Zheng Q, Xia N, Tao Y#, Li S#, Huang H#. (2022) A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode. J Nanobiotechnology 20:411
7. Tao Y*, Cheung L*, Li S, Eom J, Chen L, Xu Y, Perry K, Frommer W, Feng L. (2015) Structure of a eukaryotic SWEET transporter in a homo-trimeric complex. Nature 527:259-63
8. Tao Y, Mis M, Blazer L, Ustav M Jnr, Steinhart Z, Chidiac R, Kubarakos E, O'Brien S, Wang X, Jarvik N, Patel N, Adams J, Moffat J, Angers S, Sidhu SS. (2019) Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice. Elife 8:e46134
9. Xu Y*, Tao Y*, Cheung L*, Fan C, Chen L, Xu S, Perry K, Frommer W, Feng L. (2014) Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature 515:448-452
联系方式:
Email: taoyy@ustc.edu.cn