冯雪竹




冯雪竹, 特任研究员


1999年毕业于北京医科大学（现北京大学医学部），获临床医学学士学位。1999至2001年在北京医科大学组织胚胎学系任教。2001-2007年就读于University of Wisconsin-Madison，获分子细胞生物学博士学位。后加入干细胞公司Cellular Dynamics International Inc.,任Senior Scientist。 2014年底加入中国科学技术大学生命科学学院。

研究兴趣和方向

  1. 真核细胞中RNA的表达与加工的调节

  2. 真核生物中的转录调节机制

  3. 人全能干细胞中非编码RNA的表达与调节机制及生物学功能

代表性论文

  1. ChenmingZeng, ChenchunWeng, XiaoyangWang, Yong-HongYan, Wen-JunLi, DeminXu, MinjieHong, ShanhuiLiao, Meng-QiuDong, XuezhuFeng (*), ChaoXu(*), ShouhongGuang(*) (2019) Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation Cell Reports Volume 27, Issue 12, 18 June 2019, Pages 3561-3572. (* 共同通讯作者)

  2. Chenchun Weng (#), Joanna Kosalka (#), Ahmet C. Berkyurek (#), Przemyslaw Stempor, Xuezhu Feng, Hui Mao, Chenming Zeng, Wen-Jun Li, Yong-Hong Yan, Meng-Qiu Dong, Natalia Rosalía Morero, Cecilia Zuliani, Orsolya Barabas, Julie Ahringer, Shouhong Guang (*), and Eric A. Miska (*) (2018) The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans. Genes & Development Jan 1;33(1-2):90-102.

  3. Chengming Zhu (#), Qi Yan (#), Chenchun Weng , Xinhao Hou , Hui Mao , Dun Liu , Xuezhu Feng (*) Shouhong Guang (*) (2018) Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA. PNAS 2018 Oct 2;115(40):10082-10087. doi: 10.1073/pnas.1800974115. (* 共同通讯作者)

  4. Fei Xu (#), Xuezhu Feng (#),Xiangyang Chen, Chenchun Weng, Qi Yan, Ting Xu, Minjie Hong, and Shouhong Guang (*)（2018）A cytoplasmic Argonaute protein promotes the inheritance of RNAi. Cell Reports. 2018 May 22;23(8):2482-2494 (# 共同第一作者)

  5. Xufei Zhou#, Xuezhu Feng#, Hui Mao, Mu Li, Fei Xu,KaiHu,and Shouhong Guang（2017）RNA-dependent RNA polymerases-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway in C. elegans.Nature Structural & Molecular Biology, 2017 Mar;24(3):258-269 (# 共同第一作者)

  6. Hui Mao, Chengming Zhu, Dandan Zong, Chenchun Weng, Xiangwei Yang, Hui Huang, Dun Liu, Xuezhu Feng*, and Shouhong Guang* (2015) The Nrde pathway mediates small RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans. Current Biology , 2015 Sep 10;25(18):2398-403 (* 共同通讯作者)

  7. Chen X (#*), Liao S (#), Huang X, Xu T, Feng X, Guang S (*). (2018) Targeted Chromosomal Rearrangements via a Combinatorial Use of CRISPR/Cas9 and Cre/LoxP Technologies in Caenorhabditis elegans. G3 (Bethesda). 2018 Jul 31;8(8):2697-2707.

  8. Xiangyang Chen,Mu Li,Xuezhu Feng*,Shouhong Guang* (2015) Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans. GENETICS December 1, 2015vol. 201no. 41295-1306(* 共同通讯作者)

  9. Zhou X, Xu F, Mao H, Ji J, Meng Y,Feng X*, and Guang S*. (2014) Nuclear RNAi Contributes to the Silencing of Off-Target Genes and Repetitive Sequences in Caenorhabditis elegans. Genetics, 2014 Feb 14. (* 共同通讯作者)

  10. Feng X, Zhang J, Smuga-Otto K, Tian S, Yu J, Stewart R, Thomson JA. (2012) Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells. Stem Cells 2012 March, 30(3):46 1-70

  11. Matthew E. Brown, Elizabeth Rondon, Deepika Rajesh, Amanda Mack, Rachel Lewis,Xuezhu Feng, Laura Jo Zitur, Randall D. Learish and Emile F. Nuwaysir. (2010) Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes. PLoS ONE 2010 Jun 29;5(6)

  12. Phanstiel D,Brumbaugh J,Berggren WT,Conard K,Feng X,Levenstein ME,McAlister GC,Thomson JA,Coon JJ. (2008) Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proc Natl Acad Sci U S A. 105(11):4093-8.

  13. Xu RH, Peck RM,Li DS,Feng X, Ludwig T, Thomson JA. (2005) Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nature Methods 2(3):185-90.


联系方式：中国科学技术大学（西区）生命科学学院916室，黄山路443号，安徽省合肥市，230027

电子邮件：fengxz@@@ustc.edu.cn

实验室主页：http://staff.ustc.edu.cn/~sguang/index.html

  

  


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