李福东


博士，副教授。2002至2013年间在中国科学技术大学生命科学学院学习，获得理学学士和理学博士学位。2013年4月起在中国科学技术大学生命科学学院从事博士后和特任副研究员工作。2019年4月通过中国科学技术大学优秀人才引进，任生命科学学院副教授。主要研究方向为基因表达调控相关的生物大分子结构和功能，主要研究成果发表于Nature Communications, Cell Research, Nucleic Acids Res, J Am Chem Soc和JBC等期刊。获中国博士后科学面上基金，科学青年基金和国家自然科学联合基金资助。

 

主要研究兴趣：

基因表达调控相关的蛋白质-蛋白质，蛋白质-核酸复合物的结构与功能。

 

代表论文:（*通讯作者, #相同贡献）

  1. Kwon, S.C#., H. Jang#, S. Shen#, S.C. Baek, K. Kim, J. Yang, J. Kim, J.S. Kim, S. Wang, Y. Shi, Li F.*, and V.N. Kim*, ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8. Nucleic Acids Res, 2020. 48(19): p. 11097-11112.

  2. Zhang M.#, Li F.#, Li, K.#, Wang Z.L., Wang Y.X., He J.B., Su H.F., Zhang Z.Y., Chi C.B., Shi X.M., C.H. Yun, X.M., Z.Y. Zhang, Z.M. Liu, L.R. Zhang, D.H. Yang, M. Ma*, X. Qiao*, and Ye M.*, Functional Characterization and Structural Basis of an Efficient Di-C-glycosyltransferase from Glycyrrhiza glabra. J Am Chem Soc, 2020. 142(7): p. 3506-3512.

  3. Sun, A#., C. Gasser#, Li F.#, H. Chen, S. Mair, O. Krasheninina, R*. Micura*, and A. Ren*, SAM-VI riboswitch structure and signature for ligand discrimination. Nat Commun, 2019. 10(1): p. 5728.

  4. Yang Y, Xu Z, He C, Zhang B, Shi Y*, and Li F* Structural insights into the recognition of gamma-globin gene promoter by BCL11A. Cell research. 2019.

  5. Xie G#, Vo TV#, Thillainadesan G, Holla S, Zhang B, Jiang Y, Lv M, Xu Z, Wang C, Balachandran V, Shi Y, Li F*, and Grewal SIS*. A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing. Nat Commun. 2019;10(1):251.

  6. He C*, Liu N, Xie D, Liu Y, Xiao Y, and Li F*. Structural basis for histone H3K4me3 recognition by the N-terminal domain of the PHD finger protein Spp1. Biochem J. 2019;476(13):1957-73.

  7. Zhao Y, Zhang G, He C, Mei Y, Shi Y*, and Li F*. The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA. Cell research. 2018;28(1):130-4.

  8. Yang SF#, Sun AA#, Shi Y, Li F*, and Pickett HA*. Structural and functional characterization of the RBBP4-ZNF827 interaction and its role in NuRD recruitment to telomeres. Biochem J. 2018;475(16):2667-79.

  9. Liu J, Zhang S, Liu M, Liu Y, Nshogoza G, Gao J, Ma R, Yang Y, Wu J, Zhang J*, Li F*, and Ruan K*. Structural plasticity of the TDRD3 Tudor domain probed by a fragment screening hit. Febs J. 2018;285(11):2091-103.

  10. Xie CL, He C, Jiang YY, Yu HL, Cheng L, Nshogoza G, Ala MS, Tian CL, Wu JH, Shi YY*, and Li F*. Structural insights into the recognition of phosphorylated Hop1 by Mek1. Acta Crystallogr D. 2018;74:1027-38.

  11. Li F#, Zhao D#, Wu J*, and Shi Y*. Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition. Cell research. 2014;24(12):1490-2.

  12. He C#, Li F#, Zhang JH, Wu JH*, and Shi YY*. The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition. J Biol Chem. 2013;288(7):4692-703.

 

联系方式：

E-Mail：lifudong@ustc.edu.cn

Phone：0551-63606364



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