特任教授，博士生导师，2024年国家优秀青年（海外），2023年中国科学院百人计划-青年项目（择优）
个人简介：
国家海外高层次青年人才项目获得者（2024），中国科学院青年人才项目获得者（择优，2023），中科大附属第一医院特聘教授。博士毕业于中国科学技术大学，博士期间联合培养于北京大学（2012-2014）和哈佛医学院（2014-2016）；2016-2021年于哈佛医学院附属Dana-Farber癌症研究所，从事结构免疫学博士后研究；2021-23于哈佛-MIT-麻省总院附属Ragon研究所，任研究科学家；2023年加入中科大生命科学与医学部。长期从事生化、结构、免疫、感染性疾病等交叉学科研究。研究成果以一作或通讯发表于Science, Nat Chem Biol, Nat Commun, Cell Mol Immunol, Protein Cell, Structure等期刊上，获得Faculty Opinions推荐、“哈佛医学院华人杰出研究奖”，并获蛋白质学会、国际免疫学大会、牛津大学、爱丁堡大学及巴斯德所等国际机构邀请报告。现任hLife青年编委，Nat Commun等期刊审稿人。
研究方向
1. T细胞在胸腺中发育的分子机制
2. T/NK细胞免疫在疾病“精英控制者”中的作用机制
3. 开发用于抗原呈递、T/NK细胞识别及免疫应答相关研究的技术
4. 其他感染性疾病及肿瘤领域中的T/NK细胞免疫研究
发表论文（#为共同一作，*为共同通讯作者）
1. Li X#;Mizsei R#; Tan K; Mallis R; Duke-Cohan J; Akitsu A; Tetteh P; Dubey A; Hwang W; Wagner G; Lang M; Arthanari H; Wang J*; Reinherz E*. Pre-T cell receptors topologically sample self-ligands during thymocyte β-selection, Science【IF:44.7, 一区】, 2021, 371(6525): 181-185
2. Li X*; Singh N; Collins D; Ng R; Zhang A; Lamothe-Molina P; Shahinian P; Xu S; Tan K; Piechocka-Trocha A; Urbach J; Weber J; Gaiha G; Mbah O; Huynh T; Cheever S; Chen J; Birnbaum M; Zhou R; Walker B*; Jia-huai Wang*. Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide, Nature Communications【IF: 14.7, 一区】, 2023, 14(1) （独立一作, *共同通讯）
3.Tano-Menka R#; Singh N#; Muzhingi I#; Li X#; Mandanas M; Kaseke C; Crain C; Zhang A; Ogunshola F; Vecchiarello L; Piechocka-Trocha A; Bashirova A; Birnbaum M; Carrington M; Walker B; Gaiha. G. Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules, Structure【IF: 4.4, 一区】10.1016/j.str.2024.04.015. （#共同一作）
4. Liu C#; Yaremenko A#; Li X#; Zhou X; Liu N; You X; Chen W; Kong N; Xie T; Gaiha G*; Langer R*;Tao W*. mRNA technology for the prevention and treatment of HIV infection (#共同一作, Nature Reviews Bioengineering【IF: 33.1, 一区】accepted in principle)
5. Li L*, Tang Z, Portillo X, Arora R, Yang M, Mintzer E, Han P, Zhang Z, Majewski D, Titelman A, Plesa A, Shadpour M, McNamee S, Zheng Y*, Li X, Tam J, McGee J, Sol S, Boncimino F, Zhang Y, Mandinova A, Murphy G, Kupper T, Ma S*, Church G*. Human skin rejuvenation via mRNA. bioRxiv2025. (under review in Nature)
6. Qin R#; Zhang Y#; Shi J#, Wu P#; An C; Li Z; Liu N; Wan Z; Hua T; Li X; Lou J*; Yin W*; Chen W*. TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity, Cell Research【IF:28.1, 一区】, 2025
7. Tan K#; Chen J#; Kaku Y; Wang Y; Donius L; Khan R; Li X; Richter H; Seaman M; Walz T; Hwang W; Reinherz E*; Kim K*; Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility, Nature Communications【IF: 14.7, 一区】, 2023, 7218
8. Jiang C#; Liu J#; He S#; Xu W#; Huang R; Pan W; Li X; Dai X; Guo J; Zhang T; Inuzuka H; Wang P; Asara J; Xiao J*; Wei W*. PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Argmethylation of NPRL2, Cell Metabolism【IF: 27.7, 一区】, 2023, 35(12): 2183-2199
9. Mizsei R; Li X; Chen W; Szabo M; Wang J; Wagner G; Reinherz E*; Mallis R*. A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes, Journal of Biological Chemistry【IF: 4.0, 二区】, 2021, 296
10. Zhang A; Piechocka-Trocha A; Li X*; Walker B*. A Leucine Zipper Dimerization Strategy to Generate Soluble T Cell Receptors Using the Escherichia coli Expression System. Cells【IF: 5.1, 二区】. 2022;11(3).
11. Chen A#; Zhao W#; Li X; Sun G; Ma Z; Peng L; Shi Z; Li X; Yan J. Comprehensive oncogenic features of coronavirus receptors in glioblastoma multiforme. Frontiers in Immunology【IF: 5.7, 二区】, 2022;13.
12. Xu S, Liu Y, Li X, Liu Y, Meijers R, Zhang Y, Wang JH. The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction. Cell Discovery【IF: 13, 一区】. 2018 Feb 20; 4:8
13. Li X, Lamothe PA, Walker BD, Wang JH. Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation. Cell Mol Immunol【IF: 21.8, 一区】. 2017 Jul;14(7):631-634.
14. Li X, Lamothe PA, Ng R, Xu S, Teng M, Walker BD, Wang JH. Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection. Protein Cell【IF: 13.6, 一区】2016 Oct;7(10):761-765.
15. Chen X*, Zhao C*, Li X*, Wang T*, Li Y, Cao C, Ding Y, Dong M, Finci L, Wang JH, Li X, Liu L. Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nature Chemical Biology【IF: 12.9,一区】 2015 Jan;11(1):19-25. (*共同一作)
16. Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ. Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A.【IF: 9.58, 一区】2015 Feb 3;112(5):1517-22.
17. Li X, Teng M, Reinherz EL, Wang JH. Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβTCR Recognition during T Lineage Subset Commitment. Front Immunol.【IF: 5.7,二区】2013 Nov 22;4:383.
18.Li X, Sun J, Pan B, Zhu L, Huang X, Zhang B. ΔSACE_0065，ΔSACE_2559 and ΔSACE_2565 genes mutation in Saccharopolyspora erythraea and their effect on spore differentiation. Military Medical Sciences【中国自然科学核心期刊】. 2011 Dec; 35(12): 913-916. （本科发表）
招生招聘：
课题组招聘对生物化学、细胞分子免疫学、结构生物学、病毒或临床免疫学等方向感兴趣的博士后、特任副研究员和研究生。简历发送至xiaolongli@ustc.edu.cn。
1. 特任副研究员和博士后：具有细胞分子免疫学、结构生物学、病毒或临床免疫学等相关背景的已博士毕业或即将博士毕业的科研人员。
2. 研究生：诚挚欢迎对本课题组感兴趣的同学加入课题组，攻读学位。
联系方式：
办公室：医学与计算楼106室
Email: xiaolongli@ustc.edu.cn
网站：https://xiaolonghefei.wixsite.com/website-1
http://biomed.ustc.edu.cn/2023/0724/c31899a609295/page.htm