特任研究员。2014年本科毕业于中国科学技术大学生命科学学院，2014-2020年师从中国科学技术大学光寿红教授获得遗传学博士学位（2014-2019年）并进行博士后研究（2019-2020年）。2020年进入西班牙基因组调控研究中心（Centre for genomic regulation, CRG）英国皇家科学学会院士Ben Lehner实验室进行博士后研究。2024年加入中国科学技术大学生命科学与医学部。
课题组目前主要通过结合系统遗传学，分子生物学，计算生物学，结构生物学等理论与实验手段，以蛋白-蛋白相互作用，蛋白-小分子相互作用，蛋白变构调控机制为先行科学问题，以重要原癌基因KRAS为切人点，从事定量生物大数据的挖掘、处理与分析的研究，并进行相关方法学的建立与发展。主要研究成果发表在Nature, Genes & Development, Cell Reports等期刊上。
主要研究兴趣：
1. 定量生物大数据的挖掘处理与分析的前沿技术；
2. 生物大分子的变构调控机制；
3. 信号转导与肿瘤
发表论文：
1. Weng, C., Faure, A.J., Escobedo, A., & Lehner, B. The energetic and allosteric landscape for KRAS inhibition. Nature https://doi.org/10.1038/s41586-023-06954-0 (2023)
2. Weng, C.*, Kosalka, J.*, Berkyurek, A.C.*, Stempor, P., Feng, X., Mao, H., Zeng, C., Li, W.J., Yan, Y.H., Dong, M.Q., Morero, N. R., Zuliani, C., Barabas, O., Ahringer, J., Guang, S., Miska, E. A. (2019). The USTC co-opts an ancient machinery to drive piRNA transcription in C. elegans. Genes & Development 2019 Jan 1;33(1-2):90-102. doi: 10.1101/gad.319293.118. Epub 2018 Dec 19.
3. Zeng, C.*, Weng, C.*, Wang, X.*, Yan, Y.H.*, Li, W.J., Xu, D., Hong, M., Liao, S., Dong, M.Q., Feng, X., et al. (2019). Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation. Cell Reports 2019 Jun 18;27(12):3561-3572.e3. doi: 10.1016/j.celrep.2019.05.076
4. Wang, Y.*, Weng, C.*, Chen, X., Zhou, X., Huang, X., Yan, Y., & Zhu, C. (2020). CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA. BMC Biology, 18(1), 115.
5. Huang, X.*, Cheng, P.*, Weng, C., Xu, Z., Zeng, C., Xu, Z., Chen, X., Zhu, C., Guang, S., & Feng, X. (2021). A chromodomain protein mediates heterochromatin-directed piRNA expression. PNAS, 2021 Jul 6;118(27):e2103723118. doi: 10.1073/pnas.2103723118
6. Zhu, C.*, Yan, Q.*, Weng, C., Hou, X., Mao, H., Liu, D., Feng, X., and Guang, S. (2018). Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA. PNAS2018 Oct 2;115(40):10082-10087. doi: 10.1073/pnas.1800974115.
7. Xu, F.*, Feng, X.*, Chen, X., Weng, C., Yan, Q., Xu, T., Hong, M., and Guang, S. (2018). A Cytoplasmic Argonaute Protein Promotes the Inheritance of RNAi. Cell Reports. 2018 May 22;23(8):2482-2494. doi: 10.1016/j.celrep.2018.04.072
8. Mao, H.*, Zhu, C.*, Zong, D., Weng, C., Yang, X., Huang, H., Liu, D., Feng, X., and Guang, S. (2015). The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegans. Current Biology 2015 Sep 21;25(18):2398-403. doi: 10.1016/j.cub.2015.07.051. Epub 2015 Sep 10.
9. Sun, H., Song, J., Weng, C., Xu, J., Huang, M., Huang, Q., Sun, R., Xiao, W., & Sun, C. (2017). Association of decreased expression of the macrophage scavenger receptor MARCO with tumor progression and poor prognosis in human hepatocellular carcinoma. Journal of Gastroenterology and Hepatology, 32(5), 1107–1114.
10. Sun, C., Xu, J., Song, J., Liu, C., Wang, J., Weng, C., Sun, H., Wei, H., Xiao, W., Sun, R., & Tian, Z. (2015). The predictive value of centre tumour CD8+ T cells in patients with hepatocellular carcinoma: comparison with Immunoscore. Oncotarget, 6(34), 35602–35615.
课题组招聘：
欢迎各种背景对本课题组研究方向感兴趣的本科生、研究生、博士后、特任副研究员等联系。
联系方式：
邮箱：wcc9294@ustc.edu.cn