特任教授，博士生导师。2015年于中国科学技术大学获神经生物学博士学位，2015-2024于中国科学技术大学从事博士后、特任副研究员和副教授工作（合作导师：张智）。2024年12月至今，任中国科学技术大学特任教授，课题组长。
国家优青获得者（2024），安徽省杰出青年基金获得者（2022），中国科学院青年创新促进会会员（2022），仲英青年学者（2022），长三角神经科学青年科学家（2023）、中科大附一院特聘专家。研究工作聚焦疼痛和情绪调控的神经机制研究：1）解析了疼痛-情绪（焦虑、抑郁等）相互作用的神经环路机制；2）发现了小胶质细胞/离子通道调控神经可塑性参与疼痛和情绪形成的细胞分子机制。相关成果以第一/通讯作者（含共同）发表在 Nature Neuroscience（2篇）、Nature Communications、Neuron、Science Advance、JCI、Current Biology和Cell Reports（2篇）等期刊，其中ESI高被引论文3篇，多篇入选中国神经科学重大进展（2021）、Cell出版社中国最佳论文（2021）、iNature中国生命科学20大进展（2019）和Faculty1000推荐阅读。主持国家自然基金委优青项目、面上项目和青年基金，及中科院合肥大科学中心培育项目、中科大融合专项和青年创新重点等。
兼任安徽省神经科学学会秘书长，安徽省神经科学学会青年工作委员会主任，中国研究型医院学会神经再生与修复委员会委员，中科院青促会合肥分会委员。
研究方向：
（1）疼痛与精神障碍（抑郁、焦虑等）的病理学机制
（2）睡眠障碍的神经机制及干预调控
代表性论文：
1. Danyang Chen#, Qianqian Lou#, Xiang-Jie Song#, Fang Kang, An Liu, Changjian Zheng, Yanhua Li, Di Wang, Sen Qun, Zhi Zhang*, Peng Cao*, Yan Jin*, Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice. Nature Communications, 2024 Jan 10;15(1):449.（最后通讯作者）
2. Hong-Rui Wei#, Lan Tang#, Xin-Lu Yang#, Chang-Mao Chen, Le-Xian Li, Yu Mao, Di Wang, Fang Kang, Sen Qun, Zhi Zhang*, Peng Cao*, Yan Jin*, A microglial activation cascade across cortical regions underlies secondary mechanical hypersensitivity to amputation. Cell Reports, 2024 Feb 17; 43(2):113804.（最后通讯作者）
3. Qianqian Lou#, Hong-Rui Wei#, Danyang Chen#, Yuzhuo Zhang, Wan-Ying Dong, Sen Qun, Di Wang†, Yanli Luo†, Zhi Zhang†, Yan Jin†, A noradrenergic pathway for the induction of pain by sleep loss.Current biology, 2024 Jun 17;34(12):2644-2656.e7. DOI: 10.1016/j.cub.2024.05.005. DOI: 10.1016/j.cub.2024.05.005.（最后通讯作者）
4. Xin-Lu Yang#, Wei Gao#, Wan-Ying Dong#, Changjian Zheng, Sheng Wang, Hong-Rui Wei, Yanli Luo†, Zhi Zhang†, Yongquan Chen†, Yan Jin†, A neural circuit for alcohol withdrawal–induced hyperalgesia in a nondependent state. Science Advances, 2024. Sep 27;10(39):eadp8636. DOI: 10.1126/sciadv.adp8636.（最后通讯作者）
5. Jun-Ma Yu#, Rui Hu#, Yu Mao#, Yingju Tai, Sen Qun, Zhi Zhang*, Danyang Chen*, Yan Jin*, Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice. National Science Review, 2023 Feb 23; 10(2): nwac275.（最后通讯作者）
6. Yan Jin#, Yu Mao#, Danyang Chen, Yingju Tai, Rui Hu, Chen-Ling Yang, Jing Zhou, Lijian Chen, Xuesheng Liu, Erwei Gu, Chunhui Jia,Zhi Zhang*, Wenjuan Tao*, Thalamocortical circuits drive remifentanil-induced postoperative hyperalgesia. The Journal of Clinical Investigation, 2022 Dec 15; 132(24):e158742.（第一作者）
7. Aijun jiang#, Hongrui Wei#, Sijia Chu, Mengyuan Wang, Jinling Yan, Xing-Lei Song, Tian-Le Xu, Zhi zhang, Yan Jin*, Wei Wang*, Up-regulation of acid-sensing ion channel 1a in the anterior cingulate cortex by INF-a/NF-kB pathway contributes to diabetes-related pain. Diabetes. 2025 Mar 25: db240847.（共同通讯作者）
8. Peng Cao#, Changmao Chen#, An Liu#, Qinghong Shan, Xia Zhu, Chunhui Jia, Xiaoqi Peng, Mingjun Zhang, Zahra Farzinpour, Wenjie Zhou, Haitao Wang, Jiang-Ning Zhou, Xiaoyuan Song, Liecheng Wang, Wenjuan Tao, Changjian Zheng, Yan Zhang, Yu-Qiang Ding, Yan Jin*, Lin Xu*, Zhi Zhang*, Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines. Neuron, 2021 Aug 18; 109(16):2573-2589.（共同通讯作者）
9. Xia Zhu#, Hao-Di Tang#, Wan-Ying Dong#, Fang Kang#, An Liu, Yu Mao, Wen Xie, Xulai Zhang, Peng Cao, Wenjie Zhou, Haitao Wang, Zahra Farzinpour, Wenjuan Tao, Xiaoyuan Song, Yan Zhang, Tian Xue, Yan Jin*, Juan Li*, and Zhi Zhang*, Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states. Nature Neuroscience, 2021 Apr; 24(4):542–553.（共同通讯作者）
10. Wenjie Zhou#, Yan Jin#, Qian Meng#, Xia Zhu#, Tongjian Bai, Yanghua Tian, Yu Mao, Likui Wang, Wen Xie, Hui Zhong, Na Zhang, Min-Hua Luo, Wenjuan Tao, Haitao Wang, Jie Li, Juan Li, Ben-Sheng Qiu, Jiang-Ning Zhou, Xiangyao Li, Han Xu, Kai Wang, Xiaochu Zhang, Yong Liu, Gal Richter Levin, Lin Xu, and Zhi Zhang*, A neural circuit for comorbid depressive symptoms in chronic pain. Nature Neuroscience, 2019 Oct; 22(10):1649-1658.（共同第一作者）
11. Peng Cao#, Mingjun Zhang#, Ziyun Ni#, Xiang-jie Song, Chen-ling Yang, Yu Mao, Wenjie Zhou, Wan-ying Dong, Xiaoqi Peng, Changjian Zheng, Zhi Zhang*, Yan Jin*, and Wenjuan Tao*, Green light induces antinociception via visual-somatosensory circuits. Cell Reports, 2023 Apr 25; 42(4):112290.（共同通讯作者）
12. Yan Jin#, Qian Meng#, Lisheng Mei, Wenjie Zhou, Xia Zhu, Yu Mao, Wen Xie, Xulai Zhang, Min-Hua Luo, Wenjuan Tao, Haitao Wang, Jie Li, Juan Li, Xiangyao Liand Zhi Zhang*, A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain. Pain, 2020 Feb; 161(2):416-428.（第一作者）
13. Wei Gao#, Dan-Dan Long#, Ting-Ting Pan, Rui Hu, Dan-Yang Chen, Yu Mao, Xiao-Qing Chai, Yan Jin*, Zhi Zhang*, Di Wang*, Dexmedetomidine alleviates anxiety-like behavior in mice following peripheral nerve injury by reducing the hyperactivity of glutamatergic neurons in the anterior cingulate cortex. Biochemical Pharmacology, 2022 Dec; 206:115293.（共同通讯作者）
联系方式：jinyan@ustc.edu.cn