中国科学技术大学副教授。2010年本科毕业于吉林大学，2015年博士毕业于中国科学院上海神经所，师从王以政院士。 2016.2-2021.5先后在美国贝勒医学院、斯坦福大学任博士后、研究科学家，师从Wah Chiu院士。2021年5月入职中国科学技术大学。曾获安徽省海外引才计划青年人才项目，主持或参与了基金委面上项目、基金委青年项目、科技部重点研发、中科院国际伙伴计划、安徽省自然科学基金等项目。主要研究方向为细菌核糖体质量控制，已取得了一系列突破性研究成果。目前在国际知名期刊发表多篇SCI论文，包括Nature、Science Advances、Nature Communications、PNAS等。
代表性论文：
1. Kretsch RC#, Li S#, Pintilie G#, Palo MZ, Case DA, Das R*, Zhang K*, Chiu W*. Complex water networks visualized by cryogenic electron microscopy of RNA. Nature. 2025 Mar 11;. doi: 10.1038/s41586-025-08855-w. PubMed PMID: 40068818.
2. Yang W, Yi R, Yao J, Gao Y, Li S*, Gong Q*, Zhang K*. Structural insights into dynamics of the BMV TLS aminoacylation. Nat Commun. 2025 Feb 3;16(1):1276.
3. Zhao X, Gao Y, Gong Q, Zhang K*, Li S*. Elucidating the Architectural dynamics of MuB filaments in bacteriophage Mu DNA transposition. Nat Commun. 2024 Jul 31;15(1):6445.
4. Li M, Liu H, Hsieh KY, Zhang S, Gao Y, Gong Q, Zhang K*, Chang CI*, Li S*. Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM analysis. Fundamental Research. 2024 Apr 19.
5. Chen J#, Chen H#, Li S#, Lin X, Hu R, Zhang K*, Liu L*. Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery. Elife. 2024 Jan 5;12.
6. Li S#*, Hsieh KY#, Kuo CI, Lin TC, Lee SH, Chen YR, Wang CH, Ho MR, Ting SY, Zhang K*, Chang CI*. A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine. Nat Commun. 2023 Nov 13;14(1):7340.
7. Li S*, Palo MZ, Zhang X, Pintilie G, Zhang K*. Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nat Commun. 2023 Mar 16;14(1):1294.
8. Zhang X#, Li S#*, Pintilie G, Palo MZ, Zhang K*. Snapshots of the first-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM. Nucleic Acids Res. 2023 Feb 22;51(3):1317-1325.
9. Parsons MF#, Allan MF#, Li S#, Shepherd TR, Ratanalert S, Zhang K, Pullen KM, Chiu W, Rouskin S, Bathe M*. 3D RNA-scaffolded wireframe origami. Nat Commun. 2023 Jan 24;14(1):382.
10. Li S, Zhang K, Chiu W. Near-Atomic Resolution Cryo-EM Image Reconstruction of RNA. Methods Mol Biol. 2023;2568:179-192.
11. Su S#, Li S#, Deng T#, Gao M, Yin Y, Wu B, Peng C, Liu J, Ma J*, Zhang K*. Cryo-EM structures of human m6A writer complexes. Cell Res. 2022 Nov;32(11):982-994.
12. Li S, Palo MZ, Pintilie G, Zhang X, Su Z, Kappel K, Chiu W*, Zhang K*, Das R*. Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2209146119.
13. Zhang K#, Li S#, Wang Y, Wang Z, Mulvenna N, Yang H, Zhang P, Chen H, Li Y, Wang H, Gao Y, Wigneshweraraj S, Matthews S, Zhang K*, Liu B*. Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor. Cell Rep. 2022 Jul 5;40(1):111026.
14. Wang X#, Li S#, Jun H#, John T, Zhang K, Fowler H, Doye JPK, Chiu W*, Bathe M*. Planar 2D wireframe DNA origami. Sci Adv. 2022 May 20;8(20):eabn0039.
15. Gao R#, Tan H#, Li S#, Ma S, Tang Y, Zhang K, Zhang Z, Fan Q, Yang J*, Zhang XE*, Li F*. A prototype protein nanocage minimized from carboxysomes with gated oxygen permeability. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5).
16. Li S#, Hsieh KY#, Kuo CI, Su SC, Huang KF, Zhang K*, Chang CI*. Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex. Sci Adv. 2021 Nov 12;7(46):eabj9537.
17. Liu B#*, Li S#, Liu Y#, Chen H, Hu Z, Wang Z, Zhao Y, Zhang L, Ma B, Wang H, Matthews S, Wang Y*, Zhang K*. Bacteriophage Twort protein Gp168 is a β-clamp inhibitor by occupying the DNA sliding channel. Nucleic Acids Res. 2021 Nov 8;49(19):11367-11378.
18.Li S, Hsieh KY, Kuo CI, Lee SH, Pintilie GD, Zhang K*, Chang CI*. Complete three-dimensional structures of the Lon protease translocating a protein substrate. Sci Adv. 2021 Oct 15;7(42):eabj7835.
19.Li S, Hsieh KY, Su SC, Pintilie GD, Zhang K*, Chang CI*. Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease. J Biol Chem. 2021 Oct;297(4):101239.
联系方式：
邮箱：lishanshan@ustc.edu.cn